About William DePippo
William DePippo is a seasoned real estate executive with more than 32 years of commercial construction and development experience, having shaped over 10 million square feet of impactful projects nationwide. He is widely regarded as a strategic leader with the rare ability to connect big-picture vision with boots-on-the-ground execution.
Bill’s journey into the real estate world defies conventional expectations. A proud self-made professional, he began his career not in a boardroom, but on active construction sites—even while holding a college degree. Without a formal academic background in real estate or an MBA, Bill charted his path by working through every department of a top-tier GC/CM firm. This hands-on exposure across functions gave him an intimate understanding of the development lifecycle—knowledge he has continuously deepened through decades of relentless effort, on-the-job learning, and leadership in high-stakes projects.
William’s Story
years as an executive at a Fortune 500 Public Company
sf+ total career experience
+ total value since 2020
years in the commercial construction industry
After spending the last 20 years in high-level public real estate
Bill has been the go-to executive for executing complex, high-value real estate developments on behalf of two of the largest real estate developers in the U.S. His projects are known not just for their technical excellence but also for delivering strategic value and community impact. Throughout his career Bill has been at the helm of more than 11 million square feet of Class A space development across Greater Boston, Maryland/Washington DC, and the Research Triangle in North Carolina.
His portfolio includes
some of the most transformative projects in the life sciences and R&D space. Signature achievements include AstraZeneca’s and Horizon Therapeutics’ Maryland headquarters, RegenxBio, and MilliporeSigma’s largest North American facility. In North Carolina, Bill successfully led the development of Fujifilm Diosynth and Beam Therapeutics, overseeing a 675,000 square foot mega-campus tailored to specialized biotech and GMP manufacturing needs. Every one of his projects has been LEED-certified, many winning prestigious industry awards.
In Cambridge, Massachusetts
one of the most competitive and constrained real estate markets in the country—Bill’s leadership has delivered over 5 million square feet of residential, including 399 Binney Street, IBM HQ at 75/125 Binney, 11 Hurley Street, and 270 Third Street. Across these projects, he has applied key lessons from his prior experience – prioritizing safety across award-winning developments. He even previously led a risk management safety training program and brings that same safety-first approach to every project. Whether leading the reengineering of life science lab space or managing entitlement and sale of mixed-use developments, his work is known for speed to market, quality of execution, and maximizing long-term value.
More than just a builder, Bill is a strategist and innovator. He’s driven by a deep sense of ownership and personal accountability. Clients and teams turn to him not just to manage projects—but to lead transformations. He navigates regulatory complexity, aligns infrastructure with future market demands, and positions assets to outperform in a competitive landscape. He’s known for bringing cross-regional teams together with clarity and purpose, ensuring seamless delivery from entitlement to occupancy.
Bill earned his Bachelor of Science in History and Philosophy from Saint Joseph’s College in Maine—an unconventional academic foundation that has fueled his ability to think critically, lead ethically, and manage complexity with nuance.
William Depippo is, above all, a builder—in every sense of the word. He builds spaces that matter, teams that thrive, and value that lasts. His career stands as proof that passion, persistence, and performance will always outshine pedigree.